Sample preparation for droplet-based microfluidics

Juinn Dar Huang, Chia Hung Liu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Sample preparation plays an essential role in most biochemical reactions. Raw reactants are diluted to solutions with desirable concentration values in this process. In this paper, a survey of existing techniques addressing sample preparation on digital microfluidic biochips (DMFBs) is given. The fundamentals of DMFBs are introduced first. Next, we explain how dilution operations are performed on DMFBs and how the constraint on mixing models comes due to the DMFB architecture limit. Then, we divide the existing techniques into four groups according to the count of target concentration values as well as the number of different reactant types, and briefly introduce selected major research works in each category.

Original languageEnglish
Title of host publicationProceedings of the 14th International Symposium on Integrated Circuits, ISIC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages364-367
Number of pages4
ISBN (Electronic)9781479948338
DOIs
StatePublished - 2 Feb 2015
Event14th International Symposium on Integrated Circuits, ISIC 2014 - Singapore, Singapore
Duration: 10 Dec 201412 Dec 2014

Publication series

NameProceedings of the 14th International Symposium on Integrated Circuits, ISIC 2014

Conference

Conference14th International Symposium on Integrated Circuits, ISIC 2014
CountrySingapore
CitySingapore
Period10/12/1412/12/14

Keywords

  • Biochip
  • digital microfluidic biochip (DMFB)
  • dilution
  • lab-on-a-chip (LoC)
  • sample preparation

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