Ruthenium(II)-catalyzed C-H alkenylation/annulation cascade for the rapid synthesis of benzoimidazoisoindoles

Manikandan Selvaraju, Ying Lien Wang, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations


An efficient one pot synthesis of benzimidazole-fused isoindoles from 2-arylbenzimidazole and readily available conjugated alkenes has been explored. The developed domino strategy involved the ruthenium-catalyzed formation of two distinct C-C and C-N bonds and one new five-membered ring to afford a polycyclic molecule. The rapid and base-free reaction conditions and the broader substrate scope are salient features of this novel protocol. The ruthenium-catalyzed tandem reaction provides a direct tool for the easy and rapid access to a new benzoimidazoisoindole scaffold.

Original languageEnglish
Pages (from-to)1358-1362
Number of pages5
JournalOrganic Chemistry Frontiers
Issue number7
StatePublished - 1 Jul 2017

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