Background: Converting large undergraduate classes from the classroom to online has been an effective way to increase enrollments in high-demand courses in undergraduate education. However, challenges exist to maintaining students’ high-quality learning interaction and engagement in large online courses. This article presents a collaborative model between faculty in health sciences and instructional designers to redesign and redevelop three high-enrollment courses to online at Boise State University. Method: Health studies course faculty and eCampus instructional designers conducted this study to reflect the collaborative online course development process at Boise State. Results: The offering of high-enrollment nursing courses met enrollment demand and maintained student retention. Challenges related to instruction were addressed by using a careful course redesign process and continuous improvement. Conclusion: Implications of this educational innovation for health science educators, instructional designers, and lessons learned are provided.