Manually designing analog circuits is often considered as a difficult task that takes a lot of time. If a design automation environment is available for analog circuits, it is useful for designers to cope with the increasing challenges in advance process. In this paper, a reliability-aware circuit sizing technique is proposed to consider process variation, circuit aging, and layout-dependent effects simultaneously. A reliability-aware analog layout automation technique is also proposed to consider both placement and routing while improving the reliability of the generated layout. These reliability-aware design automation techniques have been integrated to build a complete synthesis environment from specifications to layout. As shown in the experimental results, the proposed automation flow does help designers solve the reliability issues efficiently.