A new bis(amide) derivative of diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid (H5dtpa), diethylenetriamine-N,N′,N″-triacetic-N,N″-bis(2- methoxyphenethylamide) (H3L), has been synthesized. The crystal structure of gadolinium(III) complex of H3L ([GdL]) has been determined by X-ray crystallography. The coordination sphere of Gd(III) comprises three amine nitrogens, two amide oxygens, three carboxylic acid oxygens, and one water molecule. 17O NMR shifts showed that the [DyL] complex had one inner-sphere water molecule. Relaxivity studies with the gadolinium(III) complex showed that they associate strongly with proteins leading to a significant relaxivity enhancement.
- Contrast agent
- Paramagnetic gadolinium(III) complex