Relaxivity studies and X-ray structure of Gd(III)-diethylenetriamine-N,N′,N″-triacetic acid-N,N″-bis(2-methoxyphenethylamide) as a potential contrast agent for magnetic resonance imaging

Yun-Ming Wang*, Yueh Ju Wang, Reu Sheng Sheu, Gin Chung Liu, Wen Chen Lin, Ju Hsiou Liao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

A new bis(amide) derivative of diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid (H5dtpa), diethylenetriamine-N,N′,N″-triacetic-N,N″-bis(2- methoxyphenethylamide) (H3L), has been synthesized. The crystal structure of gadolinium(III) complex of H3L ([GdL]) has been determined by X-ray crystallography. The coordination sphere of Gd(III) comprises three amine nitrogens, two amide oxygens, three carboxylic acid oxygens, and one water molecule. 17O NMR shifts showed that the [DyL] complex had one inner-sphere water molecule. Relaxivity studies with the gadolinium(III) complex showed that they associate strongly with proteins leading to a significant relaxivity enhancement.

Original languageEnglish
Pages (from-to)1147-1152
Number of pages6
JournalPolyhedron
Volume18
Issue number8-9
DOIs
StatePublished - 12 Mar 1999

Keywords

  • Contrast agent
  • MRI
  • Paramagnetic gadolinium(III) complex
  • Relaxivity

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