Relationship between protein structures and disulfide-bonding patterns

Chao Chun Chuang, Chun Yin Chen, Jinn-Moon Yang, Ping Chiang Lyu, Jenn Kang Hwang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


We found that that disulfide-bonding patterns can be used to discriminate structure similarity. Our method, based on the hierarchical clustering scheme, is applicable to proteins with two or more disulfide bonds and is able to detect the structural similarities of proteins of low sequence identities (<25%). Our results show the surprisingly close relationship between disulfide-bonding patterns and proteins structures. Our findings should be useful in protein structure modeling.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalProteins: Structure, Function and Genetics
Issue number1
StatePublished - Oct 2003


  • Disulfide-bonding patterns
  • Structure classification
  • The hierarchical clustering method

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