Regioselective one-pot three component synthesis of chiral 2-iminoselenazolines under sonication

Wong Jin Chang, Manohar V. Kulkarni, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A one-pot multi component reaction of selenoureas, which are in situ generated from l-amino esters and isoselenocyanates, with α-bromoketone under ultrasonication. Selenourea and α-bromoketones formed 2-iminoselenazoles through a Hantzsch selenazole-type reaction. The steric effect of the α-substituted bromoketones on the rate of the tandem reaction was studied to understand the reaction mechanism by isolating the key reaction intermediate, 2-iminoselenol.

Original languageEnglish
Pages (from-to)97113-97120
Number of pages8
JournalRSC Advances
Volume5
Issue number118
DOIs
StatePublished - 1 Jan 2015

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