Reduced frontal activity during a verbal fluency test in fibromyalgia: A near-infrared spectroscopy study

Po Han Chou, Kuo Tung Tang, Yi Hsing Chen*, Chia-Wei Sun, Chih-Mao Huang, Der Yuan Chen

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations


Fibromyalgia (FM) is a complex disorder characterized by widespread chronic pain and associated sleep problems and cognitive dysfunction. However, only few studies focusing on cognitive dysfunction in FM are available so far. In the present study, we aimed to use near infrared spectroscopy (NIRS) to evaluate the brain function in FM patients subjected to a verbal fluency test (VFT). A total of 11 primary FM patients and 13 healthy individuals (HC) underwent NIRS while performing a VFT. The Fibromyalgia Impact Questionnaire (FIQ) was used to evaluate the symptom severity of FM and Beck Depression Inventory II (BDI) was used to evaluate the severities depression symptoms in study participants. Five regions of interests (ROIs) were defined: the frontal-, bilateral inferior frontal gyrus (IFG), and temporal regions. Brain activities of ROIs between the two groups were compared. In addition, we investigated the relationship between clinical symptoms and brain cortical activity in FM patients. Our results showed that there were no significant differences between HC and FM patients in age, sex, and BDI scores. We found significantly reduced brain activity over the frontal regions during a VFT in FM patients (p =.026). In addition, we found decreased frontal activity was associated with BDI scores (rho = −0.755, p =.007). Furthermore, there were no significant correlations between frontal activity and FIQ subscales. In conclusion, our study demonstrated a reduced frontal cortical activity during VFT in FM patients, and that NIRS could be a potential tool for evaluating brain function in FM patients in clinical settings.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalJournal of Clinical Neuroscience
StatePublished - 1 Apr 2018


  • Brain dysfunction
  • Cognition
  • Fibromyalgia
  • Near infrared spectroscopy
  • NIRS

Fingerprint Dive into the research topics of 'Reduced frontal activity during a verbal fluency test in fibromyalgia: A near-infrared spectroscopy study'. Together they form a unique fingerprint.

  • Cite this