Red blood cell deformability upon continuous or repetitive loadings

Hiroaki Ito*, Ryo Murakami, Chia-Hung Tsai, Mitsuhiro Horade, Motomu Tanaka, Makoto Kaneko

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

This paper focuses on the comparison of red blood cell (RBC) deformability under continuous and repetitive loadings. We utilized a feedback position-control system and a narrow microfluidic channel for applying different deformation patterns on RBCs. According to the analyses of shape recoveries with different patterns, we found, for the first time, that the mechanical responses of RBCs upon continuous and repetitive loadings are almost the same within the error among cellular individualities as long as the total duration of the loading is the same. The result indicates that the internal mechanical stress on RBCs accumulates even if the apparent cell shape recovers. The finding provides quantitative insights for the systematic comparison among various exisiting measurement methods of mechanical responses of cells.

Original languageEnglish
Title of host publication2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages141-144
Number of pages4
ISBN (Electronic)9781509050789
DOIs
StatePublished - 23 Feb 2017
Event30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017 - Las Vegas, United States
Duration: 22 Jan 201726 Jan 2017

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Conference

Conference30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017
CountryUnited States
CityLas Vegas
Period22/01/1726/01/17

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