Recovery based nanowire field-effect transistor detection of pathogenic avian influenza DNA

Chih Heng Lin*, Chia Jung Chu, Kang Ning Teng, Yi Jr Su, Chii Dong Chen, Li Chu Tsai, Yuh-Shyong Yang

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Fast and accurate diagnosis is critical in infectious disease surveillance and management. We proposed a DNA recovery system that can easily be adapted to DNA chip or DNA biosensor for fast identification and confirmation of target DNA. This method was based on the re-hybridization of DNA target with a recovery DNA to free the DNA probe. Functionalized silicon nanowire field-effect transistor (SiNW FET) was demonstrated to monitor such specific DNA-DNA interaction using high pathogenic strain virus hemagglutinin 1 (H1) DNA of avian influenza (AI) as target. Specific electric changes were observed in real-time for AI virus DNA sensing and device recovery when nanowire surface of SiNW FET was modified with complementary captured DNA probe. The recovery based SiNW FET biosensor can be further developed for fast identification and further confirmation of a variety of influenza virus strains and other infectious diseases.

Original languageEnglish
Article number02BL02
JournalJapanese journal of applied physics
Volume51
Issue number2 PART 2
DOIs
StatePublished - 1 Feb 2012

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