Recent advances in liquid-phase combinatorial chemistry

Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations

Abstract

In combination with high throughput screening, combinatorial organic synthesis of large numbers of pharmaceutically interesting compounds may revolutionize the drug discovery process. Although combinatorial organic synthesis on solid supports is a useful approach, several groups are focusing their research efforts on liquid-phase combinatorial synthesis by the use of soluble polymer supports to generate libraries. This macromolecular carrier, in contrast to an insoluble matrix, is soluble in most organic solvents and has a strong tendency for precipitation in particular solvents. Liquid-phase combinatorial synthesis is a unique approach since homogeneous reaction conditions can be applied, but product purification similar to the solid- phase method can be carried out by simple filtration and washing. This method combines the positive aspects of classical solution-phase chemistry and solid-phase synthesis. This review examines the recent applications (1995- 1999) of soluble polymer supports in the synthesis of combinatorial libraries.

Original languageEnglish
Pages (from-to)299-318
Number of pages20
JournalCombinatorial Chemistry and High Throughput Screening
Volume2
Issue number6
StatePublished - 1 Dec 1999

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