Reactions of ketone dilithio α,β-dianions with imines and hydrazones: An anionic access to γ-amino ketones

Ilhyong Ryu*, Go Hei Yamamura, Sohei Omura, Satoshi Minakata, Mitsuo Komatsu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The reactions of ketone dilithio α,β-dianions with imines and hydrazones were investigated. The nucleophilic addition reaction to C-N double bonds took place selectively at the β-position of dianions to form lithium Z-enolates containing a lithium amide portion, which is then transformed into γ-amino ketones and related compounds by the subsequent reaction with electrophiles.

Original languageEnglish
Pages (from-to)2283-2286
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number14
DOIs
StatePublished - 3 Apr 2006

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