Abstract
Described is a one-flask, two-step method for the synthesis of highly functionalized piperidines. The process involves formal [4 + 2] cycloadditions of Schiff bases and Nazarov reagents, followed by facile elaborations of the initial cycloadducts. Notably, these aza-annulations are facilitated by protic solvents and proceed smoothly under ambient conditions, without other additives. The synthetic utility of this annulation protocol is further showcased through a concise, convergent synthesis of (±)-tetrabenazine.
Original language | English |
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Pages (from-to) | 8827-8831 |
Number of pages | 5 |
Journal | Organic and Biomolecular Chemistry |
Volume | 17 |
Issue number | 39 |
DOIs | |
State | Published - 21 Oct 2019 |