Quartz-based photonic crystal surfaces for multiplexed cancer biomarker detection

Cheng-Sheng Huang, V. Chaudhery, J. Polans, M. Lu, B. T. Cunningham*, A. Pokhriyal, S. George, R. C. Zangar

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report for the first time the combination of a quartz-based photonic crystal (PC) with a detection instrument designed to perform label-free (LF) and enhanced fluorescence (EF) imaging for antibody microarray applications. Label-free detection is used to quantify binding density of immobilized capture antibodies. Angle-scanning approach is implemented to achieve more uniform fluorescence enhancement by reducing the coefficient of variation of replicate assays by 20-99% compared to ordinary fluorescence microscopy.

Original languageEnglish
Title of host publicationIEEE SENSORS 2012 - Proceedings
DOIs
StatePublished - 1 Dec 2012
Event11th IEEE SENSORS 2012 Conference - Taipei, Taiwan
Duration: 28 Oct 201231 Oct 2012

Publication series

NameProceedings of IEEE Sensors

Conference

Conference11th IEEE SENSORS 2012 Conference
CountryTaiwan
CityTaipei
Period28/10/1231/10/12

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  • Cite this

    Huang, C-S., Chaudhery, V., Polans, J., Lu, M., Cunningham, B. T., Pokhriyal, A., George, S., & Zangar, R. C. (2012). Quartz-based photonic crystal surfaces for multiplexed cancer biomarker detection. In IEEE SENSORS 2012 - Proceedings [6411036] (Proceedings of IEEE Sensors). https://doi.org/10.1109/ICSENS.2012.6411036