Pulsatile drug release from PLGA hollow microspheres by controlling the permeability of their walls with a magnetic field

Wei Lun Chiang, Cherng Jyh Ke, Zi Xian Liao, San-Yuan Chen, Fu Rong Chen, Chun Ying Tsai, Younan Xia*, Hsing Wen Sung

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

Pulsatile release: When a high-frequency magnetic field is applied, heat will be generated by coupling to the iron oxide nanoparticles encapsulated in the shells of PLGA hollow microspheres. As the temperature approaches the T g of PLGA, the polymer chains become more mobile, subsequently increasing the free volume of PLGA matrix and significantly enhancing the diffusion of drug molecules.

Original languageEnglish
Pages (from-to)3584-3588
Number of pages5
JournalSmall
Volume8
Issue number23
DOIs
StatePublished - 7 Dec 2012

Keywords

  • iron oxide nanoparticles
  • magnetic stimulus
  • molecular switches
  • pulsatile drug release

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