This is the second of two companion papers describing an investigation of a full-scale three-story composite steel-concrete frame that was pseudo-dynamically and quasi-statically tested out to inter-story drift ratios of 10%. This paper summarizes the analytical studies of the test frame, including comparisons with measured response and design implications. Damage indices are investigated to help interpret the analytical results and relate the calculated engineering demand parameters to physical damage in the frame. In terms of peak displacements and overall response, the analytical and measured frame response agree fairly well up to drift ratios of about 3%. Beyond this, discrepancies occur, which are likely due to degradation effects (e.g., local flange buckling) that are not modeled in the analysis. Comparison between calculated damage indices and observed damage suggest the need for further research to improve the performance simulation tools.