Protein functionalized nanodiamond arrays

Y. L. Liu, Kien-Wen Sun

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Various nanoscale elements are currently being explored for bio-applications, such as in bio-images, bio-detection, and bio-sensors. Among them, nanodiamonds possess remarkable features such as low bio-cytotoxicity, good optical property in fluorescent and Raman spectra, and good photostability for bio-applications. In this work, we devise techniques to position functionalized nanodiamonds on self-assembled monolayer (SAMs) arrays adsorbed on silicon and ITO substrates surface using electron beam lithography techniques. The nanodiamond arrays were functionalized with lysozyme to target a certain biomolecule or protein specifically. The optical properties of the nanodiamond-protein complex arrays were characterized by a high throughput confocal microscope. The synthesized nanodiamond-lysozyme complex arrays were found to still retain their functionality in interacting with E. coli.

Original languageEnglish
Pages (from-to)1045-1050
Number of pages6
JournalNanoscale Research Letters
Volume5
Issue number6
DOIs
StatePublished - 1 Jun 2010

Keywords

  • Biosensor
  • Nanodiamond
  • Self-assembled monolayer

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