Probing the sensitivity of nanowire-based biosensors using liquid-gating

Ming Pei Lu*, Cheng Yun Hsiao, Wen Tsan Lai, Yuh-Shyong Yang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


We have used liquid-gating to investigate the sensitivity of nanowire (NW)-based biosensors for application in the field of ultrasensitive biodetection. We developed an equivalent capacitance model of the biosensor system to explore the dependence of the sensitivity on the liquid-gate voltage (Vlg), which was influenced by capacitive competition between the NW capacitance and the thin oxide capacitance. NW biosensors with highest sensitivity were obtained when we operated the device in the subthreshold regime while applying an appropriate value of Vlg; the influence of leakage paths through the ionic solutions led, however, to significant sensitivity degradation and narrowed the operating window in the subthreshold regime.

Original languageEnglish
Article number425505
Issue number42
StatePublished - 22 Oct 2010

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