Printable Graphene Oxide Micropatterns for a Bio-Subretinal Chip

Jia Wei Yang, Ming Liang Tseng, Yu Min Fu, Che Hao Kang, Yu-Ting Cheng, Po Han Kuo, Chi Kuan Tzeng, Shih Hwa Chiou, Chung-Yu Wu, Guan-Yu Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Recently, implantable artificial subretinal chips using electronic components have replaced photoreceptors to serve as the most feasible treatment for retinal diseases. As such a chip that is meant to be implanted and used for very long periods, growing retinal cells on it to improve the electrical stimulation efficiency and attraction of neuronal elements remains a challenge. Here, an inkjet printing technology is employed to create graphene oxide (GO) micropatterns onto microelectrodes of a photovoltaic-powered implantable retinal chip. These GO micropatterns allow human retinal pigment epithelium (RPE) cells to specially attach and grow in each microelectrode. In addition, the cell proliferation, viability, and tight junction of RPE cells are improved during culturing. The development of a simple surface-coating technology would pave the way for the development of the first fully integrated and encapsulated retinal prostheses with biocompatible on-chip microelectrodes for long-term implantation, which could be effectively applied in retina tissue engineering and therapy.

Original languageEnglish
Article number1800365
JournalAdvanced Healthcare Materials
Volume7
Issue number18
DOIs
StatePublished - 19 Sep 2018

Keywords

  • graphene oxide
  • inkjet printing
  • micropatterns
  • retinal pigment epithelium cells
  • subretinal chips

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