Preparation and characterization of thermal-sensitive ferrofluids for drug delivery application

Ting Yu Liu, Shang Hsiu Hu, Sheng Hsiang Hu, Szu Ping Tsai, San-Yuan Chen*

*Corresponding author for this work

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Novel thermal-sensitive ferrofluids (F127-ferrofluids) consisting of core-shell-type magnetic nanoparticles dispersed in Pluronic F127-containing aqueous solution were prepared. The core (magnet)-shell (Pluronic F127) nanoparticles were synthesized by in situ co-precipitation process, which were characterized using transmission electron microscope, X-ray diffraction and vibrating sample magnetometer. The F127-ferrofluids gelled above the lower critical solution temperatures (LCST) of approximately 23-28 °C, which were higher than that of pure Pluronic F127-fluids (21-25 °C). The increase in the LCST of the F127 ferrofluids may be attributed to a result of a physical interaction between the F127 molecules and the core-shell magnetic nanoparticles.

Original languageEnglish
Pages (from-to)2850-2852
Number of pages3
JournalJournal of Magnetism and Magnetic Materials
Volume310
Issue number2 SUPPL. PART 3
DOIs
StatePublished - 1 Mar 2007

Keywords

  • Core-shell
  • Drug delivery
  • Ferrofluid
  • Magnetic nanoparticle
  • Pluronic F127
  • Thermal sensitive

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