Preparation and characterization of magnetic ferroscaffolds for tissue engineering

Shang Hsiu Hu, Ting Yu Liu, Chia Hui Tsai, San-Yuan Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Magnetic-based scaffolds (ferroscaffolds) were fabricated using an in-situ synthesis of iron oxide nanoparticles in the presence of various concentration of biodegradable gelatin. The resulting ferroscaffolds show an interconnected pore structure with pore sizes ranging from 50 to 200 μm depending on gelatin concentrations. However, the yield of the iron oxide nanoparticles decreases with the increase of gelatin contents, which is due to the presence of polymeric chains that hindered the growth of iron oxide upon co-precipitation. The content of deposited magnetic nanoparticles could reach up to 9.41% and its saturation magnetization (Ms) was 23.5 emu/g. In addition, while applying a magnetic field (MF), the magnetic interparticles forces immediately formed to reduce the drug release rates in the ferroscaffolds. The ferroscaffolds which possess an excellently magnetic-sensitive behaviors can be potentially used as stimuli-responsive drug carriers and scaffolding materials for tissue engineering.

Original languageEnglish
Pages (from-to)2871-2873
Number of pages3
JournalJournal of Magnetism and Magnetic Materials
Volume310
Issue number2 SUPPL. PART 3
DOIs
StatePublished - 1 Mar 2007

Keywords

  • Gelatin
  • Magnetic nanoparticles
  • Scaffolds

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