Predicting the volume of tissue activated via electrode impedance during deep brain stimulation

Wei Yi Chuang*, Chang-Po Chao, Kuu-Young Young

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In a typical deep brain stimulation (DBS) process, doctors depend on the patient's response in tuning the stimulation parameters, which is time consuming. In this process, the volume of tissue activated (VTA) is an important index to describe the stimulated region for helping adjusting suitable stimulation parameters. However, the VTA is hard to measure in clinical trials. The reason is because the brain tissue along the contact of the electrode varies with time since the electrode is implanted chronically. Some previous studies have shown that electrode impedance value significantly affects the size and shape of VTA. However, there is not a precise mathematical model to further investigate the relationship between electrode impedance and VTA. This study thus uses the technique of finite element analysis (FEA) for electromagnetic field simulation, in order to quantify the impact of clinically relevant impedance variability on the VTA during DBS. Through the quantitative description, the VTA can be predicted. Doctors can then tune the stimulation parameters efficiently.

Original languageEnglish
Title of host publicationProceedings of the 8th IASTED International Conference on Biomedical Engineering, Biomed 2011
Pages77-82
Number of pages6
DOIs
StatePublished - 13 Jun 2011
EventIASTED International Conference on Biomedical Engineering, Biomed 2011 - Innsbruck, Austria
Duration: 16 Feb 201118 Feb 2011

Publication series

NameProceedings of the 8th IASTED International Conference on Biomedical Engineering, Biomed 2011

Conference

ConferenceIASTED International Conference on Biomedical Engineering, Biomed 2011
CountryAustria
CityInnsbruck
Period16/02/1118/02/11

Keywords

  • Deep brain stimulation (DBS)
  • Electromagnetic field simulation
  • Finite element analysis (FEA)
  • Impedance
  • Volume of tissue activated (VTA)

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