Portable multispectral imaging system for oral cancer diagnosis

Yao Fang Hsieh*, Yang-Mang Ou, Cheng Chung Lee

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


This study presents the portable multispectral imaging system that can acquire the image of specific spectrum in vivo for oral cancer diagnosis. According to the research literature, the autofluorescence of cells and tissue have been widely applied to diagnose oral cancer. The spectral distribution is difference for lesions of epithelial cells and normal cells after excited fluorescence. We have been developed the hyperspectral and multispectral techniques for oral cancer diagnosis in three generations. This research is the third generation. The excited and emission spectrum for the diagnosis are acquired from the research of first generation. The portable system for detection of oral cancer is modified for existing handheld microscope. The UV LED is used to illuminate the surface of oral cavity and excite the cells to produce fluorescent. The image passes through the central channel and filters out unwanted spectrum by the selection of filter, and focused by the focus lens on the image sensor. Therefore, we can achieve the specific wavelength image via fluorescence reaction. The specificity and sensitivity of the system are 85% and 90%, respectively.

Original languageEnglish
Title of host publicationUltrafast Imaging and Spectroscopy
ISBN (Print)9780819496959
StatePublished - 1 Jan 2013
EventUltrafast Imaging and Spectroscopy - San Diego, CA, United States
Duration: 25 Aug 201326 Aug 2013

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


ConferenceUltrafast Imaging and Spectroscopy
CountryUnited States
CitySan Diego, CA


  • Biological
  • Fluorescence
  • Hyperspectral
  • In vivo
  • Multispectral
  • Oral cancer

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