PML protein as a prognostic molecular marker for patients with esophageal squamous cell carcinomas receiving primary surgery

Chueh Chuan Yen*, Yen Po Tsao, Paul Chih Hsueh Chen, Yu Chung Wu, Jin Hwang Liu, Chin Chen Pan, Chun Yu Liu, Cheng Hwai Tzeng, Po Min Chen, Yann Jang Chen, Chi Hung Lin, Wen Hu Hsu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background and Objectives We evaluated the clinicopathological associations and prognostic implications of promyelocytic leukemia gene (PML) expressions in patients with esophageal squamous cell carcinomas (ESCC) receiving primary surgery. Methods Expression patterns of PML and tumor protein 53 (TP53) of 132 cases of ESCC were evaluated by immunohistochemistry and correlated with clinicopathological parameters. The Cox proportional hazards model was used to determine the prognostic influence of clinicopathological factors on progression-free survival (PFS) and overall survival (OS). Results Forty-two cases (31.82%) were classified as lost expression of PML, 25 (18.94%) as focally positive, and 65 (49.24%) as diffusely expressed. Sixty-three cases (47.73%) were classified as over-expression of TP53. High expression of TP53 and down-regulation of PML were often found in advanced disease; and, in together with high pathological staging, grading, and positive margin, were associated with poor survival. However, only tumor differentiation (P=0.016), distant metastasis (P=0.001), and PML expression (P=0.001) could act as independent prognostic factors for PFS, and LN metastasis (P=0.004), TP53 (P=0.006), and PML expression (P=0.029) were identified as independent prognostic factors for OS in multivariate analysis. Conclusions Our study demonstrated PML protein as an independent prognostic marker for patients with ESCC receiving primary surgery.

Original languageEnglish
Pages (from-to)761-767
Number of pages7
JournalJournal of Surgical Oncology
Volume103
Issue number8
DOIs
StatePublished - Jun 2011

Keywords

  • esophageal neoplasia
  • PML
  • TP53

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