Photophysical mechanisms of collagen modification by 80 MHz femtosecond laser

Vladimir Hovhannisyan, Ara Ghazaryan, Yung Fang Chen, Shean-Jen Chen, Chen Yuan Dong

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Photophysical mechanisms of collagen photomodification (CFP) by the use of a 80 MHz, 780 nm femtosecond titanium-sapphire laser were investigated. Our observation that the decrease in collagen second harmonic generation and increase in two-photon autofluorescence intensity occurred primarily at sites where photoproducts were present suggested that the photoproducts may act to facilitate the CFP process. Laser power study of CFP indicated that the efficiency of the process depended on the sixth power of the laser intensity. Furthermore, it was demonstrated that CFP can be used for bending and cutting of collagen fibers and creating 3D patterns within collagen matrix with high precision (̃2 μm).

Original languageEnglish
Pages (from-to)24037-24047
Number of pages11
JournalOptics Express
Issue number23
StatePublished - 8 Nov 2010

Fingerprint Dive into the research topics of 'Photophysical mechanisms of collagen modification by 80 MHz femtosecond laser'. Together they form a unique fingerprint.

Cite this