Photodynamic dye adsorption and release performance of natural zeolite

Vladimir Hovhannisyan*, Chen Yuan Dong, Shean-Jen Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Clinoptilolite type of zeolite (CZ) is a promising material for biomedicine and pharmaceutics due to its non-toxicity, thermal stability, expanded surface area, and exceptional ability to adsorb various atoms and organic molecules into micropores. Using multiphoton microscopy, we demonstrated that individual CZ particles produce two-photon excited luminescence and second harmonic generation signal at femtosecond laser excitation, and adsorb photo-dynamically active dyes such as hypericin and methylene blue. Furthermore, the release of hypericin from CZ pores in the presence of biomolecules is shown, and CZ can be considered as an effective material for drug delivery and controlled release in biological systems. The results may open new perspectives in application of CZ in biomedical imaging, and introducing of the optical approaches into the clinical environment.

Original languageEnglish
Article number45503
JournalScientific reports
StatePublished - 31 Mar 2017

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