Peptide Glycosylation Generates Supramolecular Assemblies from Glycopeptides as Biomimetic Scaffolds for Cell Adhesion and Proliferation

Jie Liu, Ziling Sun, Yuqi Yuan, Xin Tian, Xi Liu, Guangxin Duan, Yonggang Yang, Lin Yuan*, Hsin-Chieh Lin, Xinming Li

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Glycopeptide-based hydrogelators with well-defined molecular structures and varied contents of sugar moieties were prepared via in vitro peptide glycosylation reactions. With systematic glucose modification, these glycopeptide hydrogelators exhibited diverse self-assembling behaviors in water and formed supramolecular hydrogels with enhanced thermostability and biostability, in comparison with their peptide analogue. Moreover, because of high water content and similar structural morphology and composition to extracellular matrixes (ECM) in tissues, these self-assembled hydrogels also exhibited great potential to act as new biomimetic scaffolds for mammalian cell growth. Therefore, peptide glycosylation proved to be an effective means for peptide modification and generation of novel supramolecular hydrogelators/hydrogels with improved biophysical properties (e.g., high biostability, increased thermostability, and cell adhesion) which could promise potential applications in regenerative medicine.

Original languageEnglish
Pages (from-to)6917-6924
Number of pages8
JournalACS Applied Materials and Interfaces
Volume8
Issue number11
DOIs
StatePublished - 30 Mar 2016

Keywords

  • glycopeptide
  • hydrogel
  • peptide
  • self-assembly
  • supramolecular

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