Peak-finding algorithms

Jui-Hung Hung, Zhiping Weng

Research output: Contribution to journalArticlepeer-review


Microarray and next-generation sequencing technologies have greatly expedited the discovery of genomic DNA that can be enriched using various biochemical methods. Chromatin immunoprecipitation (ChIP) is a general method for enriching chromatin fragments that are specifically recognized by an antibody. The resulting DNA fragments can be assayed by microarray (ChIP-chip) or sequencing (ChIP-seq). This introduction focuses on ChIP-seq data analysis. The first step of analyzing ChIP-seq data is identifying regions in the genome that are enriched in a ChIP sample; these regions are called peaks.

Original languageEnglish
Pages (from-to)197-203
Number of pages7
JournalCold Spring Harbor Protocols
Issue number3
StatePublished - 1 Mar 2017

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