Partial directed coherence analysis of intracranial neural spikes in epilepsy patients

Hsiao Lung Chan*, Yu Tai Tsai, Yao Chung Wang, Ju His Ju, Bao Luen Chang, Tony Wu, Shih Tseng Lee, Bor-Shyh Lin

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

Intracranial electroencephalograms (EEG) provide a direct observation of neural activity by placing an electrode array on the cortical surface near the suspected epileptic foci. The neural spikes appeared during inter-ictal stages are mainly produced by abnormal neural discharges from epileptic foci. The topological mapping of spikes' potentials is commonly used to identify the epileptogenic zone. However, the propagations among multi-channel spikes are also important to identify the epileptic source activity. In addition, the changes of source activities in a series of consecutive spikes reveal the time-varying neural activations during discharge process, which provide alternative information for interpreting epileptic source activity. This paper proposes a spike classification based on the similarity of phase-space features to select candidate spikes from the intracranial EEGs recorded from an 8×8 electrocorticogram grid. Then, the partial directed coherence (PDC), which can provide the flow of source activity, at each spiking time point is computed. The outflow PDCs of all electrodes are therefore displayed on the grid. Our result showed that the derived source activities in the preceding spikes had high concentrated distributions but decreased in latter spikes. This implied the epileptic discharges were initially induced by a small-area cortex neurons and then spread out.

Original languageEnglish
Title of host publication2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
Pages5174-5177
Number of pages4
DOIs
StatePublished - 14 Dec 2012
Event34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States
Duration: 28 Aug 20121 Sep 2012

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Conference

Conference34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
CountryUnited States
CitySan Diego, CA
Period28/08/121/09/12

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