Parallel synthesis of amino bis-benzimidazoles by multistep microwave irradiation

Chen Hao Wu, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

A multistep liquid phase synthesis of specifically functionalized bis-benzimidazoles is presented by the application of single-mode microwave irradiation technique. The sustained solubilizing power and stability of the PEG-ester derived from the commercially available 4-fluoro-3-nitrobenzoic acid has been successfully carried through 10 steps involving ipso-SNAr reaction, neutral reduction and acid cyclization. All the steps in this synthetic sequence were assisted by microwave (MW) irradiation. The polymer support was cleaved to release the final head to tail bisbenzimidazoles in an efficient process.

Original languageEnglish
Pages (from-to)2601-2604
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number15
DOIs
StatePublished - 10 Apr 2006

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