Parallel synthesis of 1,2,3,4-tetrahydro-β-carbolines using microwave irradiation

Cheng Yi Wu, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Novel soluble polymer supported synthesis of 1,2,3,4-tetrahydro-β-carboline derivatives in the microwave oven is reported. Commercially available Fmoc-protected tryptophan was directly anchored to MeO-PEG-OH via an ester linkage in the presence of DCC and DMAP. One pot cyclocondensation of polymer-bound tryptophan with a variety of aldehydes and ketones has been carried out under microwave irradiation to provide immobilized 1,2,3,4-tetra-hydro-β-carboline derivatives. The desired products were then liberated from the soluble matrix in good yield and good purity.

Original languageEnglish
Pages (from-to)1709-1711
Number of pages3
Issue number10
StatePublished - 1 Jan 2002


  • 1,2,3,4-tetrahydro-β-carbolines
  • Combinatorial chemistry
  • Liquid-phase method
  • Microwave-assisted combinatorial synthesis
  • Scaffold

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