Parallel synthesis and biological evolution of quinic acid derivatives as immuno-suppressing agents against T-cell receptors

Chih Yu Huang, Li Hsun Chen, Hsuan Yu Huang, Feng Sheng Kao, Yun Ta Lee, Manikandan Selvaraju, Chung-Ming Sun*, Hueih Min Chen

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

A simple protocol for the synthesis of quinic acid derivatives was established and their biological evolution against T-cells is studied. Results showed that one of the derivatives, Cyn-1324, has low toxicity on T-cells and a high effect on reducing Signal 2 of T-cell immune responses. In vitro binding measurements of atomic force spectroscopy further indicated that the blocking effect of Cyn-1324 between CD28 and CD80 was about 31 ± 4%. In vivo animal tests also confirmed that Cyn-1324 can reduce the allergic responses from ovalbumin-induced mice with little toxicity. Based on these observations, Cyn-1324 can be a mild immuno-suppressive candidate for future drug development.

Original languageEnglish
Pages (from-to)50801-50806
Number of pages6
JournalRSC Advances
Volume5
Issue number63
DOIs
StatePublished - 1 Jan 2015

Fingerprint Dive into the research topics of 'Parallel synthesis and biological evolution of quinic acid derivatives as immuno-suppressing agents against T-cell receptors'. Together they form a unique fingerprint.

  • Cite this

    Huang, C. Y., Chen, L. H., Huang, H. Y., Kao, F. S., Lee, Y. T., Selvaraju, M., Sun, C-M., & Chen, H. M. (2015). Parallel synthesis and biological evolution of quinic acid derivatives as immuno-suppressing agents against T-cell receptors. RSC Advances, 5(63), 50801-50806. https://doi.org/10.1039/c5ra06095h