Palladium-catalyzed regioselective synthesis of 2(2 ′ -biphenyl)benzimidazoles through C-H activation

Li Hsun Chen, Tz Yi Wu, Vijaykumar Paike, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


An efficient palladium-catalyzed strategy through C-H bond activation for the synthesis of 2(2 ′ -biphenyl)-benzimidazoles is reported herein. The regioselective C-C bond formation proceeds in a sealed tube via oxidative C-H activation of ortho-directed 2-aryl-benzimidazole to couple with various iodobenzene analogs in high yields. This arylation exhibited high regioselectivity which is able to increase molecular diversity in difficult functionalized positions of parent molecules. This strategy provides a convenient and simple synthesis of biphenyl heterocyclic compounds with high regioselectivity. Graphical Abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)641-649
Number of pages9
JournalMolecular Diversity
Issue number4
StatePublished - 1 Nov 2013


  • Benzimidazole
  • Biphenyl heterocycles
  • C-C bond formation
  • C-H activation
  • Palladium catalyst

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