Organic molecular sensing by single metal porphyrin nanoparticles

Takayuki Uwada*, Yoichiroh Hosokawa, Noriko Takizawa, Kazunori Okano, Hiroshi Masuhara

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations


We demonstrate preparations of zinc porphyrin nanoparticles by reprecipitation method and their spectroscopic analysis by dark-field light scattering microspectroscopy. The size distribution of the prepared nanoparticles was 80-150 nm. By using dark-field illumination the nanoparticles could be observed as bright points in dark background and could be examined by their Rayleigh scattering spectra at single particle level. The spectra differed from particle to particle, which would be ascribed to their size and crystalline phase difference. Thus we have performed this single particle spectroscopic technique to remove the ambiguity about the spectroscopic information owing to distributions of particles and to improve the space selectivility. In addition, we have successfully demonstrated the detection of amine molecules in water at single particle level. These results indicate that the detection technique using the single porphyrin nanoparticles can be applied to chemical and biological sensors with nanometer scale.

Original languageEnglish
Title of host publicationNanoscale Imaging, Sensing, and Actuation for Biomedical Applications V
StatePublished - 21 Apr 2008
EventNanoscale Imaging, Sensing, and Actuation for Biomedical Applications V - San Jose, CA, United States
Duration: 21 Jan 200823 Jan 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceNanoscale Imaging, Sensing, and Actuation for Biomedical Applications V
CountryUnited States
CitySan Jose, CA


  • Biosensor
  • Metal porphyrin
  • Nanoparticles
  • Nanoscale detection
  • Rayleigh light scattering microspectroscopy

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