Since nanotechnology has been applied in various fields, it has attracted enormously worldwide investments. In the meanwhile, according to the reports of US National Science Foundation in 2002, the annual production value of nanotechnology related industries would reach one thousand billion dollars within 10-15 years. Given the bright prospect of nanotechnology in global trend, countries have undertaken numerous studies to catch the opportunity. Facing the competitions from Mainland China, Korea and several other countries, Taiwan government is eyeing on foresight strategies of nanotechnology with traditional industries in order to put effort on maintaining current leading position in the manufacturing sectors. However, Taiwan's nano-companies mostly focus on developing nano-composite products, and most products are still at developing stage or pilot stage. As regards other infrastructure development, the government still lacks an explicit goal and developing policies. Therefore, this research tends to propose an optimal executing order of developing policies in nanotechnology domain. By using the multi-objective compromise optimization method which integrating AHP with TOPSIS, we can conduct a priority of government policies executing. The optimal policies of nanotechnology could be applied by companies as their alternative developing strategies and also commissioned for enhancing the global competitive position of Taiwan.