One pot three component reaction for the rapid synthesis of pyrrolo[1,2-a]benzimidazoles

Wei Shun Hsu, Vijaykumar Paike, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


An efficient strategy for the synthesis of pyrrolo[1,2- a ]-benzimidazole (PBI) linked to an ionic liquid (ILs) as a soluble support under microwave irradiation was explored. The key intermediate benzimidazoles were synthesized via N-acylation followed by cyclodehydration of IL-supported methyl-3-amino-4-(isobutylamino) benzoate. The synthesis of the IL-bound PBI was performed by one-pot three-component condensation under microwave dielectric heating, which involved a Knoevenagel condensation and a [4+1]-cycloaddition reaction. The reaction was monitored directly by means of 1H NMR. All final products were obtained in good yield and high purity after precipitation. Graphic Abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)285-294
Number of pages10
JournalMolecular Diversity
Issue number2
StatePublished - 1 May 2013


  • Ionic liquid
  • Microwave chemistry
  • Multicomponent reaction (MCR)
  • One-pot three component
  • Pyrrolo[1, 2-a]benzimidazole
  • Soluble supported synthesis

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