Abstract
An efficient strategy for the synthesis of pyrrolo[1,2- a ]-benzimidazole (PBI) linked to an ionic liquid (ILs) as a soluble support under microwave irradiation was explored. The key intermediate benzimidazoles were synthesized via N-acylation followed by cyclodehydration of IL-supported methyl-3-amino-4-(isobutylamino) benzoate. The synthesis of the IL-bound PBI was performed by one-pot three-component condensation under microwave dielectric heating, which involved a Knoevenagel condensation and a [4+1]-cycloaddition reaction. The reaction was monitored directly by means of 1H NMR. All final products were obtained in good yield and high purity after precipitation. Graphic Abstract: [Figure not available: see fulltext.]
Original language | English |
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Pages (from-to) | 285-294 |
Number of pages | 10 |
Journal | Molecular Diversity |
Volume | 17 |
Issue number | 2 |
DOIs | |
State | Published - 1 May 2013 |
Keywords
- Ionic liquid
- Microwave chemistry
- Multicomponent reaction (MCR)
- One-pot three component
- Pyrrolo[1, 2-a]benzimidazole
- Soluble supported synthesis