One-Pot Synthesis of Unsymmetrical Bis-Heterocycles: Benzimidazole-, Benzoxazole-, and Benzothiazole-Linked Thiazolidines

Hsueh Yuan Lu, Indrajeet J. Barve, Manikandan Selvaraju, Chung Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A one-pot, three-component synthesis of benzimidazole-linked thiazolidines from 2-cyanomethyl benzimidazole, iso-, isothio-, or isoselenocyanates and 1,2-dichloroethane is reported. Isolation of the key intermediate formed during the course of the reaction validates its mechanistic pathway. Under the same reaction conditions, benzimidazole-linked/fused thiazinanes were obtained when 1,3-dichloropropane or diiodomethane was used.

Original languageEnglish
Pages (from-to)42-48
Number of pages7
JournalACS Combinatorial Science
Volume22
Issue number1
DOIs
StatePublished - 22 Nov 2019

Keywords

  • benzimidazoles
  • combinatorial chemistry
  • microwave irradiation
  • molecular diversity
  • one-pot reaction
  • three-component synthesis

Fingerprint Dive into the research topics of 'One-Pot Synthesis of Unsymmetrical Bis-Heterocycles: Benzimidazole-, Benzoxazole-, and Benzothiazole-Linked Thiazolidines'. Together they form a unique fingerprint.

Cite this