One pot synthesis of oxygenated tri-heterocycles as anti-microbial agents

Imthyaz A. Khan, Manohar V. Kulkarni*, Chung-Ming Sun

*Corresponding author for this work

Research output: Contribution to journalArticle

44 Scopus citations


A one pot synthesis of an array of angularly linked tri-heterocycles with coumarin, benzofuran and furan rings is described. This high yielding synthesis is achieved by the reaction of various 4-bromomethylcoumarins with furyl o-hydroxyphenyl ketones involving benzylic nucleophilic displacement and intramolecular aldolization. All the compounds have been tested in vitro for their anti-microbial activity against Micrococcus aureus, Pseudomonas chinchori, Asperigillus fumigatus and Penicillium wortmanni at 100, 50, and 25 μg ml-1 concentrations. Chloro groups in the benzofuran ring enhanced the activity.

Original languageEnglish
Pages (from-to)1168-1172
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Issue number11
StatePublished - 1 Nov 2005


  • Antibacterial activity
  • Coumarins
  • Tri-heterocycles

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