One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions

Shuhei Sumino, Akira Fusano, Hiroyuki Okai, Takahide Fukuyama, Ilhyong Ryu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The consecutive radical/ionic reaction consisting of radical formylation of alkyl bromides and nucleophilic addition of a cyanide ion was investigated, which gave moderate to good yields of cyanohydrin derivatives in one-pot.

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalBeilstein Journal of Organic Chemistry
Volume10
DOIs
StatePublished - 14 Jan 2014

Keywords

  • Alkyl bromide
  • Carbon monoxide
  • Cyanohydrin
  • Ethyl cyanoformate
  • Multicomponent
  • Radical reaction

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