One-pot synthesis of copper nanoconjugate materials as luminescent sensor for Fe3+ and I detection in human urine sample

Yu Ting Tai, Turibius Simon, Yun Yi Chu, Fu Hsiang Ko*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A simple synthetic approach of water-soluble and stable fluorescent copper nanoclusters (Cu NCs) at room temperature was proposed. The cysteamine functionalized nanoconjugate materials (CA-Cu NCs) exhibited variety of exceptional properties, including good water-solubility, photostability, low cytotoxicity and acting as an excellent cell imaging probe. Based on the electron transfer and aggregation induced fluorescence quenching mechanism, CA-Cu NCs were utilized in the selective determination of ferric (Fe3+) and iodide (I) ions. The detection limits of Fe3+ and I ions were calculated as 423 nM and 2.02 μM, which are lower than the maximum level of Fe3+ and I ions, allowed in drinking water by the U.S. Environmental Protection Agency. The assay method of paper strip was also successfully applied for the detection of Fe3+ and I ions in live cells and human urine.

Original languageEnglish
Article number100319
JournalSensing and Bio-Sensing Research
StatePublished - Feb 2020


  • Cell imaging
  • Copper nanoclusters
  • Cysteamine
  • Fe and I detection
  • Fluorescent assay
  • Paper strip

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