Abstract
We demonstrate a straightforward synthesis of γ-lactams possessing an α-phosphorus ylide moiety from assembly of phosphines, N-tosyl aldimines and an enyne through an initial α(δ′)-attack of phosphines to an enyne in up to 79% yield. The investigated multicomponent reaction tolerates a variety of triarylphosphines and electron-poor aldimines to give γ-lactams in one pot. One of the lactams, with the tri(p-tol)phosphine and 4-cyanophenyl moiety, exhibits fluorescence emission at 447 nm with a quantum yield of 0.11. This journal is
Original language | English |
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Pages (from-to) | 162-170 |
Number of pages | 9 |
Journal | Organic and Biomolecular Chemistry |
Volume | 12 |
Issue number | 1 |
DOIs | |
State | Published - 7 Jan 2014 |