On the classification of cancer cell gene via Expressive Value Distance (EVD) algorithm and its comparison to the optimally trained ANN method

Tong Zhang, Chi-Hsu Wang, Sik Chung Tam*, C. L.Philip Chen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

In recent years, cancer can be detected and recognized by analyzing the sample's expression profile. The cancer gene expression data are high dimensional, high variable dependent, and very noisy. The dimension reduction method is often used for processing the high dimensional data. In this study, a new statistical dimension reduction method called Expressive Value Distance (EVD) is developed and proposed for the practical high-dimensional gene expression cancer data. The feature genes data extracted by EVD are arranged for training the optimally trained Artificial Neural Network (ANN). The trained ANN is then used to classify whether the unseen gene data is cancer or not. In comparison of ANN classification with and without EVD, it is found that both of the ANN can classify the cancer data in good accuracy. With the EVD method, the great amount of data (2000 genes) can be effectively reduced to 16 genes. Therefore, EVD is an effective dimension reduction method. Even the EVD method is not used, the optimally trained ANN is also an advanced method for classifying the high dimensional and complicated cancer data. Briefly, it proves that optimally trained ANN is a very robust classification technique.

Original languageEnglish
Title of host publicationFUZZ 2011 - 2011 IEEE International Conference on Fuzzy Systems - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2199-2204
Number of pages6
ISBN (Print)9781424473175
DOIs
StatePublished - 1 Jan 2011

Publication series

NameIEEE International Conference on Fuzzy Systems
ISSN (Print)1098-7584

Keywords

  • Artificial neural network
  • Classification of cancer
  • Dimension reduction
  • Expressive value distance
  • Gene expression profile

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