On reliability hardening in cyber-physical digital-microfluidic biochips

Guan Ruei Lu, Guan Ming Huang, Ansuman Banerjee, Bhargab B. Bhattacharya, Tsung Yi Ho, Hung-Ming Chen

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

In the area of biomedical engineering, digitalmicrofluidic biochips (DMFBs) have received considerable attention, because of their capability of providing an efficient and reliable platform for conducting point-of-care clinical diagnostics. System reliability, in turn, mandates error-recoverability while implementing biochemical assays on-chip for medical applications. Unfortunately, the technology of DMFBs is not yet fully equipped to handle error-recovery from various microfluidic operations involving droplet motion and reaction. Recently, a number of cyber-physical systems have been proposed to provide real-time checking and error-recovery in assays based on the feedback received from a few on-chip checkpoints. However, in order to synthesize robust feedback systems for different types of DMFBs, certain practical issues need to be considered such as co-optimization of checkpoint placement and layout of dropletrouting pathways. For application-specific DMFBs, we propose here an algorithm that minimizes the number of checkpoints and determines their locations to cover every path in a given dropletrouting solution. Next, for general-purpose DMFBs, where the checkpoints are pre-deployed in specific locations, we present a checkpoint-aware routing algorithm such that every dropletrouting path passes through at least one checkpoint to enable error-recovery and to ensure physical routability of all droplets. Our experiments on assay benchmarks show encouraging results in terms of latest-arrival-time and routability of droplets. The proposed methods thus provide convenient reliability-hardening mechanisms for a wide class of cyber-physical DMFBs.

Original languageEnglish
Title of host publication2017 22nd Asia and South Pacific Design Automation Conference, ASP-DAC 2017
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages518-523
Number of pages6
ISBN (Electronic)9781509015580
DOIs
StatePublished - 16 Feb 2017
Event22nd Asia and South Pacific Design Automation Conference, ASP-DAC 2017 - Chiba, Japan
Duration: 16 Jan 201719 Jan 2017

Publication series

NameProceedings of the Asia and South Pacific Design Automation Conference, ASP-DAC

Conference

Conference22nd Asia and South Pacific Design Automation Conference, ASP-DAC 2017
CountryJapan
CityChiba
Period16/01/1719/01/17

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