On-chip RBC deformability checker embedded with vision analyzer

Makoto Kaneko, Takuto Ishida, Chia-Hung Tsai, Hiroaki Ito, Misato Chimura, Tatsunori Taniguchi, Tomohito Ohtani, Yasushi Sakata

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

This paper discusses an on-chip Red Blood Cell (RBC) deformability checker with vision analyzer. The system is composed of a PDMS chip including three microfluidic channels, a microscope for appropriately enlarging RBC, and a high-speed vision for observing both the cell size and behaviors in the channel, respectively. We particularly focus on how to analyze the deformability of single cells by the proposed vision analyzer. The analyzer can detect the diameter and velocity of each cell inside and outside the test channel. Based on the information, we can obtain a deformability map which shows the relationship between cell deformation and transit velocity. The results obtained by the proposed vision analyzer are compared to the manual evaluation with a tuning parameter based on gray level control. The comparison results show that the error is less than 5% between vision-based and manual evaluations.

Original languageEnglish
Title of host publication2017 IEEE International Conference on Mechatronics and Automation, ICMA 2017
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2005-2010
Number of pages6
ISBN (Electronic)9781509067572
DOIs
StatePublished - 23 Aug 2017
Event14th IEEE International Conference on Mechatronics and Automation, ICMA 2017 - Takamatsu, Japan
Duration: 6 Aug 20179 Aug 2017

Publication series

Name2017 IEEE International Conference on Mechatronics and Automation, ICMA 2017

Conference

Conference14th IEEE International Conference on Mechatronics and Automation, ICMA 2017
CountryJapan
CityTakamatsu
Period6/08/179/08/17

Keywords

  • RBC Deformability
  • Vision analyzer

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