On-Chip Cell Gym

Mitsuhiro Horade*, Chia-Hung Tsai, Hiroaki Ito, Nobuya Higashino, Takayuki Akai, Utako Yokoyama, Yoshihiro Ishikawa, Shinya Sakuma, Fumihito Arai, Makoto Kaneko

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

A novel microfluidic system for applying cyclic pressure to cells during incubation is developed and tested in this work. The cyclic pressure generates stress stimulus to the cells, and is named 'Cell Exercise' in this work. The goal of this paper is to design an 'On-Chip Cell Gym' where we can observe what happens during the cell exercise in real-time. We design the cell gym on a PDMS chip composed of two parallel chamber arrays, so that we can directly observe the difference with and without Cell Exercise. Cells in one group of chamber is cultured under cell exercise mode and the other one is under none cell exercise mode. Dramatic growth of cell stress fibers is observed in the group of cell exercise with respect to the group without any exercise.

Original languageEnglish
Title of host publication2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages603-604
Number of pages2
ISBN (Electronic)9781509050789
DOIs
StatePublished - 23 Feb 2017
Event30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017 - Las Vegas, United States
Duration: 22 Jan 201726 Jan 2017

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Conference

Conference30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017
CountryUnited States
CityLas Vegas
Period22/01/1726/01/17

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  • Cite this

    Horade, M., Tsai, C-H., Ito, H., Higashino, N., Akai, T., Yokoyama, U., Ishikawa, Y., Sakuma, S., Arai, F., & Kaneko, M. (2017). On-Chip Cell Gym. In 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017 (pp. 603-604). [7863479] (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMSYS.2017.7863479