Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles

Wen Lo, Ara Ghazaryan, Chien Hsin Tso, Po-Sheng Hu, Wei Liang Chen, Tsung Rong Kuo, Sung Jan Lin, Shean-Jen Chen, Chia Chun Chen*, Chen Yuan Dong

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles.

Original languageEnglish
Article number213701
JournalApplied Physics Letters
Volume100
Issue number21
DOIs
StatePublished - 21 May 2012

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    Lo, W., Ghazaryan, A., Tso, C. H., Hu, P-S., Chen, W. L., Kuo, T. R., Lin, S. J., Chen, S-J., Chen, C. C., & Dong, C. Y. (2012). Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles. Applied Physics Letters, 100(21), [213701]. https://doi.org/10.1063/1.3701135