Novel synthesis of liquid crystalline compounds of 5-substituted 2-(4-alkylphenyl)pyridines

Win Long Chia*, Shih Wei Shen, Hong-Cheu Lin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


This study describes a novel and efficient synthesis of pyridine-containing liquid crystalline 5-substituted 2-(4-alkylphenyl)pyridines. 4-Alkylphenylmagnesium bromide was reacted with 3-substituted N-ethoxycarbonylpyridinium chloride to give regioselective 1,2-dihydropyridine intermediates, which were subsequently oxidized by o-chloranil. Good yields and high α-regioselectivity on the pyridine ring were observed in all cases.

Original languageEnglish
Pages (from-to)2177-2179
Number of pages3
JournalTetrahedron Letters
Issue number11
StatePublished - 11 Mar 2001


  • Liquid crystalline compounds
  • Pyridine-containing compounds
  • Synthesis

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