Novel route to hydroxy(keto)ethylene dipeptide isosteres through the reaction of N- t BOC-β-lactams with enolates

Iwao Ojima*, Edward W. Ng, Chung-Ming Sun

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Ring-opening coupling reactions of (3R,4S)-1- t BOC-3-silyloxy-4-substituted-azetidin-2-ones with lithium enolates of ketones and esters take place smoothly to give the corresponding hydroxy(keto)ethylene dipeptide isosteres in high yields.

Original languageEnglish
Pages (from-to)4547-4550
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number26
DOIs
StatePublished - 26 Jun 1995

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