Novel patterns of p53 abnormality in breast cancer from Taiwan: Experience from a low-incidence area

M. Ann Lou, Su Ling Tseng, Shu Fen Chang, Chung Tai Yue, Bao Li Chang, Chi How Chou, Show Lin Yang, Bee Heong Teh, Cheng-Wen Wu Lee, Chen Yang Shen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Among 114 breast cancers in Taiwan, the prevalence of p53 mutation (22.8%) and p53 accumulation (38.3%) was similar to that in high-incidence areas. However, novel patterns of p53 abnormalities, including unique sites or types of mutation (i.e. an excessive proportion of G:C to A:T transition at CpG site), and accumulation of wild-type p53 either within nuclear or cytoplasmic compartments were noted. These may have relevance to breast cancer in Taiwan, a low-incidence area.

Original languageEnglish
Pages (from-to)746-751
Number of pages6
JournalBritish Journal of Cancer
Volume75
Issue number5
DOIs
StatePublished - 6 Mar 1997

Keywords

  • Breast
  • Cancer
  • Human
  • p53

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