Novel cyclization of bis-Boc-guanidines: Expeditive traceless synthesis of 1,3,5-oxadiazinones under microwave conditions

Gorakh S. Yellol, Tsai Wen Chung, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

A novel intramolecular cyclization was discovered during the reaction of soluble polymer supported bis-Boc-guanidines with amines under microwave irradiation, leading to an oxadiazinone skeleton. The cyclized polymer conjugates have been further utilized to generate substituted 1,3,5-oxadiazinones by a traceless synthesis.

Original languageEnglish
Pages (from-to)9170-9172
Number of pages3
JournalChemical Communications
Volume46
Issue number48
DOIs
StatePublished - 28 Dec 2010

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